Wednesday, January 22, 2014

Protein synthesis

  • START codon = AUG or GUG (rare)
  • STOP codons = UAA, UAG, UGA
  • Synthesisi of proteins activated by GTP hydrolisis
  • Ribosome advance from 5' to 3' terminal
  • tRNA activated by ATP

  • Aminoglycosides inhibit initiation complex and produce misreading of mRNA
  • Chloramphenicol inhibits 50S peptidyltransferase
  • Macrolides and Clindamycin bind 50S blocking translocation

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